Where can I read about the science behind NR?Updated 3 months ago

There is a wealth of scientific research available on nicotinamide riboside (NR) and its role as a precursor to NAD⁺ in cells. For reliable information, you can consult peer-reviewed studies and review articles in scientific journals, or the publications and evaluations of the European Food Safety Authority (EFSA).

Tip: Many of these studies are freely accessible via databases such as PubMed or via official EFSA reports.

Recommended links

1. European Food Safety Authority (EFSA) Opinion – Safety of nicotinamide riboside chloride as a novel food (2019)
   → Assessment of NR chloride (nicotinamide riboside) as a novel food for use as a source of niacin in food supplements. European Food Safety Authority
   → View the report
   
   
2. EFSA Extension of use of nicotinamide riboside chloride as a novel food (2023)
   → Update/extension of the uses of NR chloride under EU regulations. European Food Safety Authority
   → Read the PDF
   
   
3. Clinical trial – Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
   → Research into the absorption (‘bioavailability’) of NR in humans and its effect on NAD⁺ levels. 
   → Read via PubMed
   
   
4. Clinical trial – Chronic nicotinamide riboside supplementation is well tolerated and elevates NAD+ in healthy middle-aged and older adults
   → Study shows that long-term intake of NR leads to increased NAD⁺ levels without serious side effects.
   → Read via PubMed
   
   
5. Additional clinical trial – Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
   → Research in older adults, with an increase in NAD⁺ in neuron-related biomarkers. 
   → Read via PubMed
   
   
6. Clinical trial - Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
   → This study provides the first evidence that oral intake of nicotinamide riboside (NR) is safe in humans and increases blood NAD+ levels in a dose-dependent manner, with NAAD identified as a crucial indicator for this increase.
   → Read via Pubmed